A 30% Ascorbic Acid Solution in DMSO Reduced the Need for Surgery in 94% of Cutaneous Squamous Cell Carcinoma in Situ Patients

A 30% Ascorbic Acid Solution in DMSO Reduced the Need for Surgery in 94% of Cutaneous Squamous Cell Carcinoma in Situ Patients

Briant Burke, MD, MS

Medical Director Boise Research Foundation
967 E. Parkcenter Blvd, Ste 205
(208) 353-0158
bburkemd2@gmail.com

“Topical 30% Ascorbic Acid in Dimethyl Sulfoxide
for the Treatment of Cutaneous Squamous Cell Carcinoma In Situ.”
medRxiv 2025.10.13.25337920 (PDF)
(10/2026)

Interview Summary…

Dr. Briant Burke described a longstanding interest in integrative medicine, natural products, and research, rooted in his background in neuroscience and molecular biology and influenced by his mother’s experience with cancer. He said he believes potentially useful treatments should not be dismissed simply because they are natural or considered unconventional, particularly because such approaches may be low-tech, inexpensive, and safe.

Vitamin C & DMSO as A Skin Cancer Treatment…

His interest in topical vitamin C and DMSO developed from an earlier experience treating basal cell carcinoma. After finding an older study using concentrated vitamin C as a paste that required lengthy treatment, he looked for a way to improve penetration and considered DMSO. After seeing apparent success in several individuals, he extended the approach to squamous cell carcinoma in situ. Burke explained that the proposed mechanism involves high local concentrations of vitamin C producing hydrogen peroxide in the tumor environment. Cancer cells may be less able than normal cells to defend against hydrogen peroxide because they have lower levels of catalase, the enzyme that breaks down hydrogen peroxide. He explained that DMSO acts primarily as a carrier by penetrating the outer skin barrier and loosening the connections between the lipid and protein layers, while also appearing to have anti-inflammatory activity but no apparent anticancer activity by itself.

Squamous Cell Cancer in Situ Vitamin C and DMSO Study…

The squamous cell carcinoma study was an open-label trial conducted through a network of dermatology clinics associated with an osteopathic school in Alabama. Seventeen people participated, with some having multiple lesions. Participants applied the 30% ascorbic acid/DMSO solution twice daily, using a small brush to moisten the entire lesion, and were evaluated at two weeks and one, two, and three months. Burke said the three-month period was selected to provide enough time for lesions to shrink rather than prematurely classifying patients as treatment failures. The treatment was generally well tolerated; one patient developed a brisk surrounding inflammatory reaction and was instructed to stop temporarily. Almost everyone experienced at least a 70% reduction in lesion size, and the study reported that 94% avoided surgical excision, although some patients still had residual atypical cells or required additional treatment, often freezing rather than surgery. Burke said he was surprised that some lesions contained actinic atypia after the cancer had been reduced or eliminated, and this remains something he is trying to understand. His continuing goal is to develop an approach that could allow patients to apply the treatment at home until the lesion becomes completely normal skin. He also discussed future research through the Boise Research Foundation, including work on reducing chemotherapy-related heart toxicity and a proposed controlled study of fibrocystic breast disorder.

Interview Q&A…

Kirk Hamilton: Can you please share with me your educational background and current position?

Briant Burke: I received my undergraduate degree in biology, earned an M.S. in molecular biology from Yale University, and received my M.D. from the University of Connecticut School of Medicine. I am currently the medical director and founder of the Boise Research Foundation in Boise, Idaho.

KH: What got you interested in studying topical vitamin C in a DMSO carrier to treat squamous cell carcinoma lesions in situ?

BB: My office manager had a basal cell carcinoma on her face and did not want another large excisional biopsy because of the scar from a previous skin cancer procedure. I came across a Hungarian study using concentrated vitamin C as a paste but the treatment took about five months. I thought the treatment needed better penetration and a trial of DMSO with the vitamin C seemed logical. After the vitamin C and DMSO were applied to her lesion it dissolved away in approximately two or three weeks. A couple of other personal acquaintances subsequently had similar problems, so I tried the approach again and it appeared to work. I then extended the approach to squamous cell carcinoma.

KH: What got you interested in integrative medicine and less invasive approaches to treatment?

BB: My interest in integrative medicine is longstanding. I believe the important distinction in medicine is between what works and what does not, rather than between mainstream and natural approaches. I believe natural approaches deserve closer examination because they may be low-tech, inexpensive, and safe and could have wide applicability in primary care.

KH: Where did your interest in research come from?

BB: I started out in research, with a primary interest in neuroscience. While working at the medical school at Yale, my mentor encouraged me to attend medical school. My mother’s experience battling cancer also shifted my perspective. After medical school, I chose family practice because I liked the variety of problems and patients.

KH: Where did your interest in natural products and plants come from?

BB: It came from a love of plants and a fundamental belief that healing properties exist in the natural world and in plants and that researchers have to look for them. He pointed out that traditional medicine has a long history of finding pharmaceuticals from plants.

KH: How did your early work with natural treatments develop?

BB: When my daughter developed Molluscum Contagiosum I wanted to find something less traumatic than freezing or blistering agents for a four-year-old. I experimented with formulas, and a tea tree oil and iodine treatment worked for her. I put the information on the internet, which generated interest from other parents. I later developed other research projects from observations and problems encountered in my medical practice, including menstrual migraine.

KH: What was the original experience that led you to investigate vitamin C and DMSO for skin cancer?

BB: An old study from Hungary used concentrated ascorbic acid as a paste under a bandage for approximately 10 hours a day, and treatment took five months. This is not clinically practical, so I looked for a way to improve penetration. I tried DMSO with vitamin C, and the treatment appeared to work on a basal cell lesion. I subsequently tried it in additional individuals and then moved on to squamous cell carcinoma.

KH: What are the proposed mechanisms of how the topical vitamin C and DMSO solution works?

BB: The current thinking is that topical vitamin C penetrates the outer skin layers and reaches the tumor cells at a very high local concentration. The vitamin C may produce hydrogen peroxide locally. One hypothesis for why cancer cells are affected more than normal cells is that cancer cells are less able to defend themselves against hydrogen peroxide because they have lower levels of catalase. Catalase is the enzyme that deactivates peroxide, and normal cells are better able to defend against it.

KH: Why did you choose a 30% concentration of ascorbic acid?

BB: He said 30% is about the maximum concentration that can be obtained in water.

KH: Does DMSO have any anti-cancer properties, or is it primarily a carrier for vitamin C?

BB: DMSO does not appear to have any anticancer activity by itself. It does appear to have anti-inflammatory activity. DMSO is a good organic solvent that can penetrate the fatty layer of the outer skin and loosen the connections between the layers, helping substances pass through the skin barrier.

KH: Does DMSO do anything beyond helping vitamin C penetrate the skin?

BB: DMSO appears to suppress inflammation, which is an active component of cancer transformation. Vitamin C undergoes oxidation-reduction readily in water, whereas DMSO is an aprotic solvent (an aprotic solvent means it is a liquid that can dissolve many substances without having any “acidic” hydrogen atoms attached to oxygen or nitrogen atoms that it can easily donate) and should make vitamin C more stable until it reaches the aqueous environment of the cell.

KH: How is the 30% vitamin C/DMSO solution prepared?

BB: The prescription would specify a 30% weight/volume solution of ascorbic acid in DMSO. Thirty grams of vitamin C would be used per 100 milliliters of final solution. The pharmacist cannot simply put 30 grams of vitamin C into 100 milliliters of DMSO because the final volume would be greater than 100 milliliters. Instead, the pharmacist would add some DMSO, mix in the vitamin C, and then add enough additional DMSO to reach the proper final volume.

KH: Can patients treat skin cancer with this on their own?

BB: No. Treating cancer is never a do-it-yourself project. Anyone considering use the vitamin C and DMSO treatment should talk with their doctor, use a compounding pharmacist, have regular visits, and monitor what is happening.

KH: Can you tell us about your study and the basic results?

BB: It was an open-label trial, meaning the patients knew they were receiving vitamin C and the physicians knew what they were giving them. There was no placebo and no blinding. Patients with biopsy-confirmed squamous cell carcinoma were given the option of standard surgical removal, other topical treatments, or participation in the study. Seventeen people participated, and some had two or three lesions. The treatment was applied twice daily. Patients were evaluated at two weeks, one month, two months, and three months. Almost everyone experienced a significant reduction, described as 70% or greater shrinkage of the lesion.

KH: Why was the study conducted through clinics associated with an osteopathic school in Alabama?

BB: I registered the clinical trial with the NIH’s clinicaltrials.gov registry. An enterprising resident associated with the Alabama clinic network contacted me after finding the study through the registry and asked whether I was still enrolling patients. The clinics had an extensive series of dermatology clinics, providing a large amount of patients allowing the study to reach its numbers more quickly.

KH: How many people participated in the study?

BB: There were 17 participants, and some participants had two or three lesions.

KH: How often were the patients evaluated?

BB: They came in at two weeks, one month, two months, and three months.

KH: How was the treatment applied?

BB: The dose was one application twice a day. A small brush applied approximately 25 microliters, depending on lesion size, and patients were instructed to apply enough to moisten the entire lesion. The solution was placed in an amber glass vial with a screw top and a small brush attached. Patients dipped the brush into the solution, brushed it onto the lesion, and replaced the cap.

KH: How long is the solution stable after the bottle is opened?

BB: We are not sure how long it remains stable, so each patient received a new bottle each month.

KH: Why did you choose a three-month treatment period?

BB: We wanted a long enough period for the treatment to work. If we ended the study too early, they might have had to biopsy a lesion while it was still shrinking and classify it as a failure even though there was clear evidence that it was getting smaller, crusting, and going away.

KH: What side effects occurred with the vitamin C/DMSO treatment?

BB: One patient had such a brisk reaction that there was some surrounding inflammation. The patient was instructed to stop the application for a few days and allow things to calm down. Other than that the treatment was well tolerated.

KH: How does the tolerability compare with other topical treatments for squamous cell carcinoma?

BB: Imiquimod, sold under the brand name Aldara, and 5-fluorouracil are other topical treatments. Approximately 10% to 20% of patients receiving those treatments develop enough irritation and inflammation that they stop treatment. The vitamin C approach appeared to avoid this problem.

KH: What results from the study have given you the most satisfaction or excitement for potential public benefit? A 94% avoidance of surgical excision seems impressive.

BB: Almost everyone had a significant reduction in the lesion, with 70% or greater shrinkage. The study showed that 94% did not have to undergo excision. However, some patients still had residual squamous cell carcinoma or abnormal cells and required additional treatment. In almost all of those cases, the lesion had become small enough that it could be frozen rather than surgically removed.

KH: What happened when biopsies showed abnormal cells even after the cancer had been reduced?

BB: I was surprised that some patients had residual abnormal cells on biopsy. They were not cancerous but were atypical. The pathologist described these as actinic atypia, meaning the cells were abnormal but not yet cancer. I am still puzzled why these cells still required treatment and why the cancer would disappear while abnormal cells remained.

KH: Would you extend the study beyond three months to determine whether continued treatment would eliminate the remaining atypical cells?

BB: Ideally but we did not extend the study to six months.

KH: What was the most surprising or unexpected result from the study?

BB: I was surprised by the number of patients whose biopsies showed residual abnormal cells that were not cancer but were atypical. I hoped to see the cancer simply change into normal tissue, as appeared to happen with basal cell carcinoma. The persistence of actinic atypia remains something that puzzles me.

KH: What is your ultimate goal for improving this treatment?

BB: The ideal situation would be to send a patient home with a bottle or prescription, have the patient apply it twice a day, and have the lesion become completely normal skin after a few weeks or months. My goal is to make the treatment safe, effective, and convenient for patients.

KH: Have you tried the treatment on other skin lesions, such as “aging spots” or seborrheic keratoses?

BB: No. I have not tried it on those lesions. I know that vitamin C has been used by dermatologists for fine wrinkles, but one of my patient tried this treatment on wrinkles around her eye and it did not appear to do anything.

KH: What is the current focus of the Boise Research Foundation?

BB: I want to continue research, including work related to anthracycline toxicity. Anthracyclines are a widely used class of chemotherapy for solid tumors and are highly effective, but their use is limited by toxicity to the heart. I am working on animal models investigating how to make these drugs less toxic or identify something that could protect the heart while the chemotherapy is being administered.

KH: What other research projects are being considered by the foundation?

BB: There is a project involving fibrocystic breast disorder, which is very common but has no real medical treatment. There is anecdotal evidence in the alternative medicine literature involving high-dose iodine, iodine and magnesium, but there have not been many properly controlled clinical trials. He said the foundation’s next major thrust may be conducting rigorous studies that are blinded, include a placebo, and produce results that can be presented to the medical establishment.

KH: Are there any other comments you would like to make about this important subject?

BB: I am still trying to find ways to improve the treatment. I described the ideal result as a treatment that patients could apply at home twice a day and that would eventually produce completely normal skin. I enjoyed the interview and will keep you informed of further papers on this subject.

(AI assisted summary and Q & A of interview transcript only reviewed by Kirk Hamilton PA and Briant Burke MD, MS)

Partial Publications List by Briant Burke, MD, MS
(Alternative and Complementary Medicine)

Burke BD, Miller P, Ward J, Morgan M (2025) Topical 30% Ascorbic Acid in Dimethyl Sulfoxide for the Treatment of Cutaneous Squamous Cell Carcinoma In Situ. medRxiv 2025.10.13.25337920; doi: https://doi.org/10.1101/2025.10.13.25337920

Burke BE, Baillie JE (2024) Randomized placebo controlled trial of phytoterpenes in DMSO for the treatment of plantar fasciitis. Sci Rep 14, 17621 (2024). https://doi.org/10.1038/s41598-024-65979-1; open access.

Burke BE, Baillie JE (2022) Randomized trial of topical ascorbic acid in DMSO versus imiquimod for the treatment of basal cell carcinoma. Biomed Pharmacother 148; open access.

Burke BE, Markum E, Baillie J. (2012) Combination of essential oil of Melaleuca alternifolia and iodine in the treatment of molluscum contagiosum in children Journal of Drugs in Dermatology 11 (3): 349-54.

Burke BE, Baillie JE, Olson RD (2004) Essential oil of Australian lemon myrtle (Backhousia citriodora) in the treatment of molluscum contagiosum in children. Biomed Pharmacother 58;245-7.

Burke BE, Olson RD, Cusack BJ (2002) Randomized, controlled trial of phytoestrogen in the prophylactic treatment of menstrual migraine Biomed Pharmacother 56: 321-327.

Burke BE, Neuenschwander RA, Olson RD (2001) Randomized, double-blind, placebo controlled trial of coenzyme Q10 in isolated systolic hypertension. South Med J 94:1112-1117.

Highlights…

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Nutrition, Prevention and Integrative Medicine…

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Cancer…

BREAST CANCER – IVERMECTIN – MEBENDAZOLE – CBD – MCP – 45 year old California woman with Stage 4 Breast Cancer reports after 18 months: NED. William Makis, MD, Makis Health, 9/30/26.

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Societal and World Health…

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KILLING FIELDS – COMMUNISM – GENOCIDE – Warnings from Cambodia’s Killing Fields (Graphic Post). I traveled to Phnom Penh to understand one of communism’s darkest and most violent chapters. Ngo Comment, 9/30/26.

SEX OFFENDERS – WOMEN’S PRISONS – How a California Bill Lets Sex Offenders Into Women’s Prisons | YouTube 52:57 min:sec. Amie Ichikawa, American Thought Leaders, Jan Jekielek, Epoch times, Oct-03-2026.

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